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April 11, 2025
Polynucleotides: a breakthrough in Regenerative Medicine
What Are Polynucleotides?
Polynucleotides are long-chain biopolymers composed of nucleotide monomers, the building blocks of DNA. These molecules play a crucial role in cell communication, tissue repair, and skin regeneration. Due to their biocompatibility and ability to interact with cellular processes, polynucleotides have gained significant interest in biomedical research and clinical applications.
Mechanism of Action: How Polynucleotides Work?
Polynucleotides exert their effects primarily through:
- Cell Proliferation and Regeneration: Polynucleotides increase fibroblast viability and favor their proliferation. Moreover, they enhance Pro-collagen I production, improving skin elasticity and resilience.
- Preservation of the extracellular matrix (ECM), by reducing the level of MMP-1, which are enzymes that degrade the ECM.
- Anti oxidative properties, by neutralizing free radicals that contribute to oxidative stress leading to cellular aging and inflammation.
- Anti-inflammatory Properties: Polynucleotides modulate the immune response, reducing inflammation and promoting faster healing in damaged tissues.
Therapeutic Applications of Polynucleotides
Thanks to their regenerative and bio-stimulatory properties, polynucleotides are widely used in several medical fields:
- Aesthetic and Dermatological Treatments
Polynucleotides are used in injectables and topical treatments to enhance skin quality, reduce fine lines, and improve hydration. They are particularly effective in restoring skin elasticity and treating signs of aging.
- Wound Healing and Tissue Repair
Their ability to accelerate cell regeneration makes polynucleotides valuable in wound healing, post-surgical recovery, and scar treatment.
- Ophthalmology
Polynucleotide-based therapies are being explored for treating dry eye syndrome and corneal injuries due to their anti-inflammatory and regenerative effects.
- Orthopedics
Polynucleotides contribute to the repair of tendons, cartilage, and ligaments, offering potential solutions for treating musculoskeletal injuries and osteoarthritis.
Sustainable and Safe Sourcing: Polynucleotides from wild salmon
At HTL Biotechnology, safety, efficacy and sustainability are at the heart of our commitments. Our polynucleotides are derived from wild salmon from Alaska, a region renowned for the purity of its waters and the absence of industrial pollution. These salmon thrive in a pristine natural environment, free from antibiotics, growth hormones or contaminants associated with intensive aquaculture.
In addition, the salmon used by HTL Biotechnology is caught as part of the food industry, making polynucleotide extraction a co-product of sustainable fishing practices. This ensures that no additional environmental burdens are created solely for the production of biopolymers.
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