Developing New Applications

Innovation

Developing New Applications

Innovation in partnership

HTL aims to go beyond the limits of today’s uses of its biopolymers, deliver concrete progress and create real breakthroughs for medical products and for human health. To realize this vision of innovation, HTL promotes innovation in partnership, which increases creativity and technology transfers, and accelerates innovation projects.

Call for partnership

HTL offers to share its expertise, technology watch and worldwide interdisciplinary network and support innovation projects involving academic and private labs, as well as industrial players.

Collaboration is open at various levels: Technical, Networking and Intellectual Property.

  • In terms of processes, materials and equipment, scale-up, analytics but also regulatory concerns, HTL can contribute by sharing knowledge and know-how or acting as an R&D subcontractor
  • HTL is in a position to enhance collaboration between different types of industries, private laboratories, academic research…
  • Financial contributions can also be discussed.

Are you interested in innovation partnership? Click here to contact us.

Advanced medical applications

Glycosaminoglycans such as Hyaluronic Acid, Heparosan and Chondroitin, have an increasing role as promising biomaterials for innovative medical applications. A few leading examples are the development of scaffolds for regenerative medicine, the use in implantology as a shield for surgical sites and a wound healing promoter and the research on targeted therapies for cancer treatment.

Scaffold for tissue engineering in regenerative medicine and medical research

Hyaluronic Acid and Hyaluronic Acid derivatives can be used for the design of scaffolds for 3D cell cultures. Such scaffolds are designed to mimic the natural extra-cellular matrix and physically guide tissue growth in 3 dimensions. In-vitro, biomimetic 3D cell cultures are used as efficient models for medical research, including research on the effect of anticancer drugs on cancer cells. In-vivo, 3D scaffolds are promising for the regeneration of the living tissues. Hyaluronic Acid can also be used for the formulation of printable hydrogel inks.

Implants and prosthetics

The excellent biocompatibility of Hyaluronic Acid, as well as its positive effects on wound and bone healing, can be leveraged in implantology and prosthetics. Hyaluronic Acid gels have been successfully used to enhance bone repair and promote bone integration. They are also increasingly used in oral surgery as a biological barrier to shield the surgical site and prevent bacterial contamination. Thanks to its biocompatibility and resorbability, Hyaluronic Acid is a safe and efficient alternative to more conventional materials that have not been entirely satisfactory. Generally speaking, the development of glycosaminoglycan-based biomaterials supports the acceleration of innovation in the field of medical implants and prosthetics.

Targeted cancer therapy

Targeted therapy is a cancer treatment that uses drugs and works by targeting the cancer’s specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. Hyaluronic Acid is the primary ligand for receptor CD44, which is overexpressed in many tumor cells, and is therefore a potential target in cancer therapy. Hyaluronic Acid and its derivatives are good candidates for both anticancer drug carrying and targeting, as they have shown promising results in the composition of antitumoral conjugates and drug delivery systems. The development of pro-drugs surface-modified nanoparticles, microparticles, liposomes, hydrogels and other drug carriers using Hyaluronic Acid is one avenue worth exploring and is extensively investigated. Heparosan is also being investigated as a drug carrier when used for liposome coating.