Functionalized Glycosaminoglycan derivatives (GAG derivatives)

HTL offers the tailor-made development of functionalized derivatives of Glycosaminoglycans, such as modified Hyaluronic Acid and Heparosan. Developing new functionalities by chemical modification allows the optimization of existing uses of these biopolymers, but also opens opportunities for new medical applications.

New functionalities thanks to chemical modification

• Optimizing physico-chemical properties
  • Viscodynamic properties
  • Solubility in biological media
• Delaying degradation
  • Extended half-life
  • Improved resistance to oxidative stress and catabolic enzymes
• Modulating biological properties
  • Tissue adhesion
  • Tissue integration
  • Tissue improvement
  • Targeted delivery

Typical chemical modifications

• Hydrazidation
• Epoxy grafting
• Sulfation
• Silylation
• Deacetylation

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