Applications

Hyaluronic Acid

Today’s medical applications of our products

For years, Hyaluronic Acid has been improving lives of millions of patients worldwide.

Today, it is mainly used in aesthetics (as a dermal filler), dermatology (wound healing), ophthalmology (for ophthalmic surgery and eye drops), rheumatology (for visco-supplementation and bone regeneration) and urology (treatment of vesicoureteral reflux). It is also used for the coating of medical devices and surgical adhesion prevention in gastro-enterology.

Advanced medical applications are also being developed using Hyaluronic Acid as a drug carrier for targeted cancer treatment, as a biomaterial for 3D cell cultures and tissue engineering, and for implants and for prostheses. Click here to learn more.

Aesthetics

In cosmetic surgery, HTL’s Hyaluronic Acid is an essential material for wrinkle filling and skin rejuvenation. Hyaluronic Acid is mainly used to reduce wrinkles in the face, particularly to fight the signs of aging.

Skin is in a state of permanent renewal: skin cells die and are renewed daily. With time, cells regenerate themselves less quickly, and the production of some molecules loses intensity, resulting in skin aging and wrinkles. There is a growing trend for the adoption of solutions to compensate or reduce the loss of skin firmness, elasticity and volume on the face and hands. Among wrinkle filling products, injectable Hyaluronic Acid is the preferred biomaterial to produce dermal fillers due to its 3 to 24-months efficacy, reversible effects, low secondary effects and affordability. Hyaluronic Acid crosslinking contributes to modulating effect and duration.

Dermatology

In dermatology, HTL‘s Hyaluronic Acid enables wound healing, enhancement of the cicatrization process and the treatment of skin diseases.

Endogenous Hyaluronic Acid is known for sustaining wound healing and re-epithelialization processes. This is why Hyaluronic Acid is used in topical formulations such as wound dressings, films or hydrogels, for the treatment of skin irritations and wounds including abrasions, post-surgical incisions, metabolic and vascular ulcers and burns. Hyaluronic Acid can also be used in dermal injections for scar reduction.

Hyaluronic Acid is also investigated as a topical drug delivery system or as a topical treatment for skin diseases. The wound healing properties of Hyaluronic Acid and Hyaluronic Acid derivatives are also being explored in other medical fields such as ophthalmology, otolaryngology, rhinology and odontology.

Opthalmology

Hyaluronic Acid provided by HTL is widely used in ophthalmology, for both ophthalmic surgery (predominantly cataract surgery) and the treatment of dry eye and red eye syndrome.

Hyaluronic Acid is a natural component of the human eye and has been used in ophthalmic products for decades. It is widely used in ophthalmic surgery, mostly for cataract surgery, but also for glaucoma and corneal transplantation. Cataracts are among the WHO priority eye diseases, as being responsible for 51% of global blindness. In this very common surgical intervention, Hyaluronic Acid solutions are the most used visco-surgical devices. With their viscoelastic and rheological properties, they protect and lubricate the eye tissues, allow tissues to stay in place and maintain the eye shape by replacing lost vitreous fluid and provide space for manipulation.

Ocular dryness is caused by a chronic lack of sufficient lubrication and moisture on the surface of the eye. It causes visual discomfort that can lead to irritation of the cornea and eye infections. The prevalence of ocular dryness is dramatically increasing: almost one-third of the adult population could be affected by this disease. Hyaluronic Acid is used as an active ingredient in many eye drops or artificial tears, which hydrate the ocular surface, improve vision and comfort, and allow contact lenses wearers to wear their lenses comfortably. Functionalized Hyaluronic Acid derivatives can also be used to increase ocular residence time.

Rheumatology

In rheumatology, HTL’s Hyaluronic Acid is the key component of visco-supplements for the symptomatic treatment of osteoarthritis.

Hyaluronic Acid is one of the major lubricating agents of the synovial joint fluid, which absorbs mechanical impacts and avoids friction between the bone-ends. When this fluid is reduced or inflamed, disorders such as rheumatoid arthritis and osteoarthritis occur. Osteoarthritis, a chronic, degenerative disease of joint cartilage, is the most common joint disease in the world, affecting 10% to 15% of the population. Hyaluronic Acid is used as a visco-supplement to treat and slow down the progression of this disease. For cases involving severe and continuous pain resistant to pain treatment, Hyaluronic Acid is injected in the articulation to decrease pain. Patients with beginning to severe osteoarthritis may also benefit from Hyaluronic Acid-based slow-acting anti-arthritics.

Urology

In urology, HTL’s Hyaluronic Acid enables the treatment of vesicoureteral reflux (VUR), a congenital pediatric disease. VUR has a low prevalence, but its implications can be severe, including kidney pain and even chronic kidney failure. Hyaluronic Acid is used for endoscopic injections, which have a very high success rate.

Preliminary evidence has shown that intravesical Hyaluronic Acid, administered alone or in combination with chondroitin sulfate or alpha-blockers, could be able to reduce the recurrence and symptoms of urinary tract infections.

Gastroenterology

For gastro-intestinal surgery, HTL provides Hyaluronic Acid for the prevention of tissue adhesion.

Following gastro-intestinal surgery, postoperative adhesions frequently occur as a consequence of surgical trauma. Peritoneal adhesions are pathological bonds that can result in complications.

Hyaluronic Acid is increasingly used in the composition of barrier materials with positive effects on preventing postoperative adhesion and their clinical implications.